Mutasynthesis of Lincomycin Derivatives with Activity against Drug-Resistant Staphylococci

The lincomycin biosynthetic gene lmbX was deleted in Streptomyces lincolnensis ATCC 25466, and deletion of this gene led to abolition of lincomycin production. The results of complementation experiments proved the blockage in the biosynthesis of lincomycin precursor 4-propyl-l-proline. Feeding this...

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Bibliografiska uppgifter
Huvudupphovsmän: Ulanova, Dana, Novotná, Jitka, Smutná, Yvona, Kameník, Zdeněk, Gažák, Radek, Šulc, Miroslav, Sedmera, Petr, Kadlčík, Stanislav, Plháčková, Kamila, Janata, Jiří
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2010
Ämnen:
Chemistry; Biosynthesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812159/
https://ncbi.nlm.nih.gov/pubmed/19917754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00918-09
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