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Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid
Adenylation domains CcbC and LmbC control the specific incorporation of amino acid precursors in the biosynthesis of lincosamide antibiotics celesticetin and lincomycin. Both proteins originate from a common L-proline-specific ancestor, but LmbC was evolutionary adapted to use an unusual substrate,...
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| Gepubliceerd in: | PLoS One |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5730197/ https://ncbi.nlm.nih.gov/pubmed/29240815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189684 |
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