Adaptation of an L-Proline Adenylation Domain to Use 4-Propyl-L-Proline in the Evolution of Lincosamide Biosynthesis

Clinically used lincosamide antibiotic lincomycin incorporates in its structure 4-propyl-L-proline (PPL), an unusual amino acid, while celesticetin, a less efficient related compound, makes use of proteinogenic L-proline. Biochemical characterization, as well as phylogenetic analysis and homology mo...

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Detalhes bibliográficos
Main Authors: Kadlčík, Stanislav, Kučera, Tomáš, Chalupská, Dominika, Gažák, Radek, Koběrská, Markéta, Ulanová, Dana, Kopecký, Jan, Kutejová, Eva, Najmanová, Lucie, Janata, Jiří
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874040/
https://ncbi.nlm.nih.gov/pubmed/24386435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084902
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