New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C–C Bond?

Structurally different and functionally diverse natural compounds – antitumour agents pyrrolo[1,4]benzodiazepines, bacterial hormone hormaomycin, and lincosamide antibiotic lincomycin – share a common building unit, 4-alkyl-L-proline derivative (APD). APDs arise from L-tyrosine through a special bio...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Jiraskova, Petra, Gazak, Radek, Kamenik, Zdenek, Steiningerova, Lucie, Najmanova, Lucie, Kadlcik, Stanislav, Novotna, Jitka, Kuzma, Marek, Janata, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780272/
https://ncbi.nlm.nih.gov/pubmed/27014201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.00276
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