Mutasynthesis of Lincomycin Derivatives with Activity against Drug-Resistant Staphylococci

The lincomycin biosynthetic gene lmbX was deleted in Streptomyces lincolnensis ATCC 25466, and deletion of this gene led to abolition of lincomycin production. The results of complementation experiments proved the blockage in the biosynthesis of lincomycin precursor 4-propyl-l-proline. Feeding this...

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Detalhes bibliográficos
Main Authors: Ulanova, Dana, Novotná, Jitka, Smutná, Yvona, Kameník, Zdeněk, Gažák, Radek, Šulc, Miroslav, Sedmera, Petr, Kadlčík, Stanislav, Plháčková, Kamila, Janata, Jiří
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812159/
https://ncbi.nlm.nih.gov/pubmed/19917754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00918-09
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