SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

SCY-635 is a novel nonimmunosuppressive cyclosporine-based analog that exhibits potent suppression of hepatitis C virus (HCV) replication in vitro. SCY-635 inhibited the peptidyl prolyl isomerase activity of cyclophilin A at nanomolar concentrations but showed no detectable inhibition of calcineurin...

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Main Authors: Hopkins, Sam, Scorneaux, Bernard, Huang, Zhuhui, Murray, Michael G., Wring, Stephen, Smitley, Craig, Harris, Richard, Erdmann, Frank, Fischer, Gunter, Ribeill, Yves
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2010
Ábhair:
Antiviral Agents
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812147/
https://ncbi.nlm.nih.gov/pubmed/19933795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00660-09
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