A Calcineurin-Independent Mechanism of Angiogenesis Inhibition by a Nonimmunosuppressive Cyclosporin A Analog

Cyclosporin A (CsA) is a widely used immunosuppressant drug. Its immunosuppressive activity occurs through the inhibition of the protein phosphatase calcineurin via formation of a ternary complex with cyclophilin A (CypA). CsA also inhibits endothelial cell proliferation and angiogenesis. This has b...

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Bibliographic Details
Main Authors: Nacev, Benjamin A., Low, Woon-Kai, Huang, Zhennian, Su, Tina T., Su, Zhuang, Alkuraya, Hisham, Kasuga, Dan, Sun, Woong, Träger, Mario, Braun, Manfred, Fischer, Gunter, Zhang, Kang, Liu, Jun O.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Chemotherapy, Antibiotics, and Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141903/
https://ncbi.nlm.nih.gov/pubmed/21562139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180851
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