Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases

Accumulation of the synaptic protein α-synuclein (α-syn) is a hallmark of Parkinson's disease (PD) and Lewy body disease (LBD), a heterogeneous group of disorders with dementia and parkinsonism, where Alzheimer's disease and PD interact. Accumulation of α-syn in these patients might be ass...

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Bibliographic Details
Main Authors: Spencer, Brian, Potkar, Rewati, Trejo, Margarita, Rockenstein, Edward, Patrick, Christina, Gindi, Ryan, Adame, Anthony, Wyss-Coray, Tony, Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812014/
https://ncbi.nlm.nih.gov/pubmed/19864570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4390-09.2009
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