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Mad2 prolongs DNA damage checkpoint arrest caused by a double-strand break via a centromere-dependent mechanism

Eukaryotic cells employ a suite of replication and mitotic checkpoints to ensure the accurate transmission of their DNA. In budding yeast, both the DNA damage checkpoint and the spindle assembly checkpoint (SAC) block cells prior to anaphase [1-5]. The presence of a single unrepaired double-strand b...

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Bibliografski detalji
Glavni autori: Dotiwala, Farokh, Harrison, Jacob C., Jain, Suvi, Sugawara, Neal, Haber, James E.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811853/
https://ncbi.nlm.nih.gov/pubmed/20096585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.12.033
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