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Intended transcriptional silencing with siRNA results in gene repression through sequence-specific off-targeting
Transcriptional gene silencing has been reported with siRNA targeting the promoter region of genes. We tested several siRNAs directed against the human VEGF promoter. Of these, siVFp(−992) exhibited ≥50% suppression of VEGF production in two human cell lines. To determine the specificity of this siR...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811671/ https://ncbi.nlm.nih.gov/pubmed/20026621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1808510 |
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