Rationally designed siRNAs without miRNA-like off-target repression

Small interfering RNAs (siRNAs) have been developed to intentionally repress a specific gene expression by directing RNA-induced silencing complex (RISC), mimicking the endogenous gene silencer, microRNAs (miRNAs). Although siRNA is designed to be perfectly complementary to an intended target mRNA,...

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Bibliografiske detaljer
Udgivet i:BMB Rep
Main Authors: Seok, Heeyoung, Jang, Eun-Sook, Chi, Sung Wook
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society for Biochemistry and Molecular Biology 2016
Fag:
Perspective
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915226/
https://ncbi.nlm.nih.gov/pubmed/26839153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.3.019
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