siRNAs can function as miRNAs

With the discovery of RNA interference (RNAi) and related phenomena, new regulatory roles attributed to RNA continue to emerge. Here we show, in mammalian tissue culture, that a short interfering RNA (siRNA) can repress expression of a target mRNA with partially complementary binding sites in its 3′...

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Main Authors: Doench, John G., Petersen, Christian P., Sharp, Phillip A.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2003
Teme:
Research Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC195999/
https://ncbi.nlm.nih.gov/pubmed/12600936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1064703
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