In vitro synthesis of heparosan using recombinant Pasteurella multocida heparosan synthase PmHS2

In vertebrates and bacteria, heparosan the precursor of heparin is synthesized by glycosyltransferases via the stepwise addition of UDP-N-acetylglucosamine and UDP-glucuronic acid. As heparin-like molecules represent a great interest in the pharmaceutical area, the cryptic Pasteurella multocida hepa...

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Bibliographic Details
Main Authors: Chavaroche, Anaïs A. E., Springer, Jan, Kooy, Floor, Boeriu, Carmen, Eggink, Gerrit
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2009
Subjects:
Biotechnologically Relevant Enzymes and Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811250/
https://ncbi.nlm.nih.gov/pubmed/19756580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-009-2214-2
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