A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2

BACKGROUND: HIV-1 and HSV-2 are responsible for two intersecting epidemics in which the disease caused by one virus facilitates transmission and pathogenesis by the other. Therefore, suppression of one virus infection will affect the other. Acyclovir (ACV), a common antiherpetic drug, was shown to d...

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Bibliografiska uppgifter
Huvudupphovsmän: Vanpouille, Christophe, Lisco, Andrea, Derudas, Marco, Saba, Elisa, Grivel, Jean-Charles, Brichacek, Beda, Scrimieri, Francesca, Schinazi, Raymond, Schols, Dominique, McGuigan, Christopher, Balzarini, Jan, Margolis, Leonid
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811219/
https://ncbi.nlm.nih.gov/pubmed/20085496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/650343
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