A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G(2)/M DNA Damage Checkpoint

DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage checkpoints has been studied extensively, molecular...

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Main Authors: van Vugt, Marcel A. T. M., Gardino, Alexandra K., Linding, Rune, Ostheimer, Gerard J., Reinhardt, H. Christian, Ong, Shao-En, Tan, Chris S., Miao, Hua, Keezer, Susan M., Li, Jeijin, Pawson, Tony, Lewis, Timothy A., Carr, Steven A., Smerdon, Stephen J., Brummelkamp, Thijn R., Yaffe, Michael B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811157/
https://ncbi.nlm.nih.gov/pubmed/20126263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000287
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