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Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1
Catalytic inhibition of Topoisomerase II during G2 phase delays onset of mitosis due to the activation of the so-called decatenation checkpoint. This checkpoint is less known compared with the extensively studied G2 DNA damage checkpoint and is partially compromised in many tumor cells. We recently...
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| Veröffentlicht in: | FEBS J |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7483426/ https://ncbi.nlm.nih.gov/pubmed/32144855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15280 |
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