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Conformational Preferences of Substrates for Human Prolyl 4-Hydroxylase

Prolyl 4-hydroxylase (P4H) catalyzes the post-translational hydroxylation of (2S)-proline (Pro) residues in procollagen strands. The resulting (2S,4R)-4-hydroxyproline (Hyp) residues are essential for the folding, secretion, and stability of the collagen triple helix. Even though its product (Hyp) d...

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Hlavní autoři: Gorres, Kelly L., Edupuganti, Ram, Krow, Grant R., Raines, Ronald T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810141/
https://ncbi.nlm.nih.gov/pubmed/18702512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8009373
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