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Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates
Collagen is the most abundant protein in animals. A variety of indications are associated with the overproduction of collagen, including fibrotic diseases and cancer metastasis. The stability of collagen relies on the posttranslational modification of proline residues to form (2S,4R)-4-hydroxyprolin...
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| Publicado no: | Bioorg Med Chem |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4552733/ https://ncbi.nlm.nih.gov/pubmed/26022078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.05.003 |
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