Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant

OBJECTIVE: In type 1 diabetes, allogeneic pancreatic islet transplant restores insulin production, but life-threatening immunosuppression is required to avoid graft rejection. Induction of antigen (Ag)–specific tolerance by cell therapy with regulatory T-cells (Tregs) represents an attractive altern...

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Autores principales: Gagliani, Nicola, Jofra, Tatiana, Stabilini, Angela, Valle, Andrea, Atkinson, Mark, Roncarolo, Maria-Grazia, Battaglia, Manuela
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809952/
https://ncbi.nlm.nih.gov/pubmed/19934002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1168
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