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Rapamycin Prevents and Breaks the Anti-CD3–Induced Tolerance in NOD Mice

OBJECTIVE: Non–Fc-binding anti-CD3–specific antibodies represent a promising therapy for preserving C-peptide production in subjects with recent-onset type 1 diabetes. However, the mechanisms by which anti-CD3 exerts its beneficial effect are still poorly understood, and it is questionable whether t...

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Detalhes bibliográficos
Main Authors: Valle, Andrea, Jofra, Tatiana, Stabilini, Angela, Atkinson, Mark, Roncarolo, Maria-Grazia, Battaglia, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661605/
https://ncbi.nlm.nih.gov/pubmed/19151201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1432
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