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Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice

The destruction of beta cells in type 1 diabetes (T1D) results in loss of insulin production and glucose homeostasis. Treatment of non-obese diabetic (NOD) mice with immune-depleting/modulating agents (e.g., anti-CD3, murine anti-thymocyte-globulin (mATG)) can lead to diabetes reversal. However, for...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Gagliani, Nicola, Jofra, Tatiana, Posgai, Amanda L., Atkinson, Mark A., Battaglia, Manuela
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651367/
https://ncbi.nlm.nih.gov/pubmed/26580221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142318
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