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Protease-Sensitive Synthetic Prions

Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc). Frequently, PrP(Sc) is protease-resistant but protease-sensitive (s) prions have been isolated in humans and other animals. We report he...

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Bibliografiske detaljer
Main Authors: Colby, David W., Wain, Rachel, Baskakov, Ilia V., Legname, Giuseppe, Palmer, Christina G., Nguyen, Hoang-Oanh B., Lemus, Azucena, Cohen, Fred E., DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809756/
https://ncbi.nlm.nih.gov/pubmed/20107515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000736
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