Two Multiplex Assays That Simultaneously Identify 22 Possible Mutation Sites in the KRAS, BRAF, NRAS and PIK3CA Genes

Recently a number of randomized trials have shown that patients with advanced colorectal cancer do not benefit from therapies targeting the epidermal growth factor receptor when their tumors harbor mutations in the KRAS, BRAF and PIK3CA genes. We developed two multiplex assays that simultaneously sc...

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Bibliografiske detaljer
Main Authors: Lurkin, Irene, Stoehr, Robert, Hurst, Carolyn D., van Tilborg, Angela A. G., Knowles, Margaret A., Hartmann, Arndt, Zwarthoff, Ellen C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809099/
https://ncbi.nlm.nih.gov/pubmed/20098682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008802
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