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Simultaneous identification of 36 mutations in KRAS codons 61and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit

BACKGROUND: Retrospective analyses in the West suggest that mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA are negative predictive factors for cetuximab treatment in colorectal cancer patients. We developed a novel multiplex kit detecting 36 mutations in KRAS codons 61 and 146, BRAF, NR...

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Podrobná bibliografie
Hlavní autoři:	Bando, Hideaki, Yoshino, Takayuki, Shinozaki, Eiji, Nishina, Tomohiro, Yamazaki, Kentaro, Yamaguchi, Kensei, Yuki, Satoshi, Kajiura, Shinya, Fujii, Satoshi, Yamanaka, Takeharu, Tsuchihara, Katsuya, Ohtsu, Atsushi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BioMed Central 2013
Témata:	Technical Advance
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3844320/ https://ncbi.nlm.nih.gov/pubmed/24006859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-405
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Simultaneous identification of 36 mutations in KRAS codons 61and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit

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