Simultaneous identification of 36 mutations in KRAS codons 61and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit

BACKGROUND: Retrospective analyses in the West suggest that mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA are negative predictive factors for cetuximab treatment in colorectal cancer patients. We developed a novel multiplex kit detecting 36 mutations in KRAS codons 61 and 146, BRAF, NR...

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Autori principali: Bando, Hideaki, Yoshino, Takayuki, Shinozaki, Eiji, Nishina, Tomohiro, Yamazaki, Kentaro, Yamaguchi, Kensei, Yuki, Satoshi, Kajiura, Shinya, Fujii, Satoshi, Yamanaka, Takeharu, Tsuchihara, Katsuya, Ohtsu, Atsushi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Technical Advance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844320/
https://ncbi.nlm.nih.gov/pubmed/24006859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-405
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