Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

BACKGROUND: KRAS mutations in codons 12 and 13 are established predictive biomarkers for anti-EGFR therapy in colorectal cancer. Previous studies suggest that KRAS codon 61 and 146 mutations may also predict resistance to anti-EGFR therapy in colorectal cancer. However, clinicopathological, molecula...

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Main Authors: Imamura, Yu, Lochhead, Paul, Yamauchi, Mai, Kuchiba, Aya, Qian, Zhi Rong, Liao, Xiaoyun, Nishihara, Reiko, Jung, Seungyoun, Wu, Kana, Nosho, Katsuhiko, Wang, Yaoyu E, Peng, Shouyong, Bass, Adam J, Haigis, Kevin M, Meyerhardt, Jeffrey A, Chan, Andrew T, Fuchs, Charles S, Ogino, Shuji
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051153/
https://ncbi.nlm.nih.gov/pubmed/24885062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-135
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