Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

PURPOSE: Mutations in PIK3CA (the gene encoding the p110α catalytic subunit of phosphatidylinositide-3-kinase, PI3K) play an important role in colorectal carcinogenesis. Experimental evidence suggests that PIK3CA exon 9 and exon 20 mutations trigger different biological effects, and that concomitant...

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Autors principals: Liao, Xiaoyun, Morikawa, Teppei, Lochhead, Paul, Imamura, Yu, Kuchiba, Aya, Yamauchi, Mai, Nosho, Katsuhiko, Qian, Zhi Rong, Nishihara, Reiko, Meyerhardt, Jeffrey A, Fuchs, Charles S, Ogino, Shuji
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628835/
https://ncbi.nlm.nih.gov/pubmed/22357840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2410
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