Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation

Abnormalities of fatty acid metabolism are recognized to play a significant role in human disease, but the mechanisms remain poorly understood. Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step in mitochondrial fatty acid oxidation (FAO). We produced a mouse model of LCAD deficienc...

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Auteurs principaux: Kurtz, David M., Rinaldo, Piero, Rhead, William J., Tian, Liqun, Millington, David S., Vockley, Jerry, Hamm, Doug A., Brix, Amy E., Lindsey, J. Russell, Pinkert, Carl A., O’Brien, William E., Wood, Philip A.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1998
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC28088/
https://ncbi.nlm.nih.gov/pubmed/9861014
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