Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation

Abnormalities of fatty acid metabolism are recognized to play a significant role in human disease, but the mechanisms remain poorly understood. Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step in mitochondrial fatty acid oxidation (FAO). We produced a mouse model of LCAD deficienc...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Kurtz, David M., Rinaldo, Piero, Rhead, William J., Tian, Liqun, Millington, David S., Vockley, Jerry, Hamm, Doug A., Brix, Amy E., Lindsey, J. Russell, Pinkert, Carl A., O’Brien, William E., Wood, Philip A.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1998
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28088/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9861014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15592
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