Medium-Chain Acyl-CoA Dehydrogenase Deficiency in Gene-Targeted Mice

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common inherited disorder of mitochondrial fatty acid β-oxidation in humans. To better understand the pathogenesis of this disease, we developed a mouse model for MCAD deficiency (MCAD(−/−)) by gene targeting in embryonic stem (ES) ce...

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Detalhes bibliográficos
Main Authors: Tolwani, Ravi J, Hamm, Doug A, Tian, Liqun, Sharer, J. Daniel, Vockley, Jerry, Rinaldo, Piero, Matern, Dietrich, Schoeb, Trenton R, Wood, Philip A
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2005
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1189074/
https://ncbi.nlm.nih.gov/pubmed/16121256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0010023
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