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Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate
Sodium phenylbutyrate is used for treating urea cycle disorders, providing an alternative for ammonia excretion. Following conversion to its CoA ester, phenylbutyryl-CoA is postulated to undergo one round of β-oxidation to phenylacetyl-CoA, the active metabolite. Molecular modeling suggests that med...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504130/ https://ncbi.nlm.nih.gov/pubmed/23141465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.10.009 |
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