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3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of the Class I Histone Deacetylases
3,3′-Diindolylmethane (DIM) is an anti-cancer agent that induces cell cycle arrest and apoptosis through unknown mechanisms. Here, we report that DIM selectively induced proteasome-mediated degradation of the class I histone deacetylases (HDAC1, HDAC2, HDAC3, and HDAC8) in colon cancer cells, withou...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808120/ https://ncbi.nlm.nih.gov/pubmed/20068155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1924 |
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