Lanean...
PROTAC-Mediated Degradation of Class I Histone Deacetylase Enzymes in Corepressor Complexes
We have identified a proteolysis targeting chimera (PROTAC) of class I HDACs 1, 2 and 3. The most active degrader consists of a benzamide HDAC inhibitor, an alkyl linker, and the von Hippel-Lindau E3 ligand. Our PROTAC increased histone acetylation levels and compromised colon cancer HCT116 cell via...
Gorde:
| Argitaratua izan da: | Chem Commun (Camb) |
|---|---|
| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2020
|
| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610821/ https://ncbi.nlm.nih.gov/pubmed/32201871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc01485k |
| Etiketak: |
Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
|