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PROTAC-Mediated Degradation of Class I Histone Deacetylase Enzymes in Corepressor Complexes
We have identified a proteolysis targeting chimera (PROTAC) of class I HDACs 1, 2 and 3. The most active degrader consists of a benzamide HDAC inhibitor, an alkyl linker, and the von Hippel-Lindau E3 ligand. Our PROTAC increased histone acetylation levels and compromised colon cancer HCT116 cell via...
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610821/ https://ncbi.nlm.nih.gov/pubmed/32201871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc01485k |
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