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Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death

ABSTRACT Despite the good options for the management of Diffuse large B‐cell lymphoma (DLBCL), a significant percentage of patients either do not respond to current treatments or relapse after a short time. Thus, a wider palette of targeted therapeutic strategies is needed. Histone deacetylases (HDA...

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Hoofdauteurs: Abdullah Alraddadi, Joshua P. Smalley, Wael Alzahrani, Anes Saleh, Fares Al‐Mansour, Buwei He, Thong H. Cao, Sandrine Jayne, Martin Dyer, James T. Hodgkinson, Donald J. L. Jones, Shaun M. Cowley, Salvador Macip
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Wiley 2025-08-01
Reeks:eJHaem
Onderwerpen:
apoptosis
DLBCL
HDAC
HDAC inhibitors
PROTAC
Online toegang:https://doi.org/10.1002/jha2.70127
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