Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca(2+) sensitivity in human myocardium

Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effects of PKCα- and PKCε-mediated phosphorylation on my...

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Hlavní autoři: Kooij, Viola, Boontje, Nicky, Zaremba, Ruud, Jaquet, Kornelia, dos Remedios, Cris, Stienen, Ger J. M., van der Velden, Jolanda
Médium: Artigo
Jazyk:Inglês
Vydáno: D. Steinkopff-Verlag 2009
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Original Contribution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807945/
https://ncbi.nlm.nih.gov/pubmed/19655190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-009-0053-z
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