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An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Mitosis is controlled by multiple protein kinases, many of which are abnormally expressed in human cancers. Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper mitotic progression. We determined the atomic structure of Nek7 and discovered an autoinhibited conformation that sugge...

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Bibliografiske detaljer
Main Authors: Richards, Mark W., O'Regan, Laura, Mas-Droux, Corine, Blot, Joelle M.Y., Cheung, Jack, Hoelder, Swen, Fry, Andrew M., Bayliss, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807034/
https://ncbi.nlm.nih.gov/pubmed/19941817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.038
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