An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

Mitosis is controlled by multiple protein kinases, many of which are abnormally expressed in human cancers. Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper mitotic progression. We determined the atomic structure of Nek7 and discovered an autoinhibited conformation that sugge...

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Huvudupphovsmän: Richards, Mark W., O'Regan, Laura, Mas-Droux, Corine, Blot, Joelle M.Y., Cheung, Jack, Hoelder, Swen, Fry, Andrew M., Bayliss, Richard
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807034/
https://ncbi.nlm.nih.gov/pubmed/19941817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.038
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