Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

Fibroblast growth factor (FGF) 23 inhibits renal phosphate reabsorption by activating FGF receptor (FGFR) 1c in a Klotho-dependent fashion. The phosphaturic activity of FGF23 is abrogated by proteolytic cleavage at the RXXR motif that lies at the boundary between the FGF core homology domain and the...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Goetz, Regina, Nakada, Yuji, Hu, Ming Chang, Kurosu, Hiroshi, Wang, Lei, Nakatani, Teruyo, Shi, Mingjun, Eliseenkova, Anna V., Razzaque, Mohammed S., Moe, Orson W., Kuro-o, Makoto, Mohammadi, Moosa
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806769/
https://ncbi.nlm.nih.gov/pubmed/19966287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902006107
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky