αKlotho is a Non-Enzymatic Molecular Scaffold for FGF23 Hormone Signaling

The aging suppressor αKlotho binds to the fibroblast growth factor receptor (FGFR). This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion/vitamin D homeostasis. The role and mechanism of this co-receptor are unknown. Here we present the atomic structure of a 1:1:1 ter...

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Bibliografiska uppgifter
I publikationen:Nature
Huvudupphovsmän: Chen, Gaozhi, Liu, Yang, Goetz, Regina, Fu, Lili, Jayaraman, Seetharaman, Hu, Ming-Chang, Moe, Orson W., Liang, Guang, Li, Xiaokun, Mohammadi, Moosa
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007875/
https://ncbi.nlm.nih.gov/pubmed/29342138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25451
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