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αKlotho is a Non-Enzymatic Molecular Scaffold for FGF23 Hormone Signaling
The aging suppressor αKlotho binds to the fibroblast growth factor receptor (FGFR). This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion/vitamin D homeostasis. The role and mechanism of this co-receptor are unknown. Here we present the atomic structure of a 1:1:1 ter...
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| Izdano u: | Nature |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6007875/ https://ncbi.nlm.nih.gov/pubmed/29342138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25451 |
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