Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

Fibroblast growth factor (FGF) 23 inhibits renal phosphate reabsorption by activating FGF receptor (FGFR) 1c in a Klotho-dependent fashion. The phosphaturic activity of FGF23 is abrogated by proteolytic cleavage at the RXXR motif that lies at the boundary between the FGF core homology domain and the...

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Main Authors: Goetz, Regina, Nakada, Yuji, Hu, Ming Chang, Kurosu, Hiroshi, Wang, Lei, Nakatani, Teruyo, Shi, Mingjun, Eliseenkova, Anna V., Razzaque, Mohammed S., Moe, Orson W., Kuro-o, Makoto, Mohammadi, Moosa
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806769/
https://ncbi.nlm.nih.gov/pubmed/19966287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902006107
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