Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia

UV B (UVB) radiation induces clones of cells mutant for the p53 tumor suppressor gene in human and murine epidermis. Here we reanalyze large datasets that report the fate of clones in mice subjected to a course of UVB radiation, to uncover how p53 mutation affects epidermal progenitor cell behavior....

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Hlavní autoři: Klein, Allon M., Brash, Douglas E., Jones, Philip H., Simons, Benjamin D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806764/
https://ncbi.nlm.nih.gov/pubmed/20018764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909738107
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