Escaping the stem cell compartment: Sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

Once mutated, a single cell must expand into a clone before becoming significant for carcinogenesis. The forces driving clonal expansion and the obstacles that must be overcome are poorly understood. In a genetic mechanism, acquiring a second mutation conferring a proliferative advantage would enabl...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zhang, Wengeng, Remenyik, Eva, Zelterman, Daniel, Brash, Douglas E., Wikonkal, Norbert M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61147/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707578/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241353198
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