Involvement of the Toll-like receptor 4 pathway and use of TNF-α antagonists for treatment of the mucopolysaccharidoses

Enzyme replacement therapy is currently available for three of the mucopolysaccharidoses (MPSs) but has limited effects on the skeletal lesions. We investigated the involvement of the Toll-like receptor 4 (TLR4) signaling pathway in the pathogenesis of MPS bone and joint disease, and the use of the...

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Detaylı Bibliyografya
Asıl Yazarlar: Simonaro, Calogera M., Ge, Yi, Eliyahu, Efrat, He, Xingxuan, Jepsen, Karl J., Schuchman, Edward H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806747/
https://ncbi.nlm.nih.gov/pubmed/20018674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912937107
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