Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI

BACKGROUND: Although enzyme replacement therapy (ERT) is available for several lysosomal storage disorders, the benefit of this treatment to the skeletal system is very limited. Our previous work has shown the importance of the Toll-like receptor 4/TNF-alpha inflammatory pathway in the skeletal path...

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Detalhes bibliográficos
Main Authors: Eliyahu, Efrat, Wolfson, Theodore, Ge, Yi, Jepsen, Karl J., Schuchman, Edward H., Simonaro, Calogera M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159569/
https://ncbi.nlm.nih.gov/pubmed/21887218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022447
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