Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

BACKGROUND: We previously demonstrated the benefits of daily, oral pentosan polysulfate (PPS) treatment in a rat model of mucopolysaccharidosis (MPS) type VI. Herein we compare these effects to once weekly, subcutaneous (sc) injection. The bioavailability of injected PPS is greater than oral, sugges...

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Detalhes bibliográficos
Main Authors: Frohbergh, Michael, Ge, Yi, Meng, Fanli, Karabul, Nesrin, Solyom, Alexander, Lai, Alon, Iatridis, James, Schuchman, Edward H., Simonaro, Calogera M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071040/
https://ncbi.nlm.nih.gov/pubmed/24964042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100882
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