Bone marrow mesenchymal stem cells from infants with MLL-AF4(+) acute leukemia harbor and express the MLL-AF4 fusion gene

MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development is difficult to ascertain. The bone marrow (BM) microenvironment plays an important role in the pathogenesi...

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Détails bibliographiques
Auteurs principaux: Menendez, Pablo, Catalina, Purificación, Rodríguez, René, Melen, Gustavo J., Bueno, Clara, Arriero, Mar, García-Sánchez, Félix, Lassaletta, Alvaro, García-Sanz, Ramón, García-Castro, Javier
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806455/
https://ncbi.nlm.nih.gov/pubmed/19995953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091050
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