Bone marrow mesenchymal stem cells from infants with MLL-AF4(+) acute leukemia harbor and express the MLL-AF4 fusion gene

MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development is difficult to ascertain. The bone marrow (BM) microenvironment plays an important role in the pathogenesi...

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Detalhes bibliográficos
Main Authors: Menendez, Pablo, Catalina, Purificación, Rodríguez, René, Melen, Gustavo J., Bueno, Clara, Arriero, Mar, García-Sánchez, Félix, Lassaletta, Alvaro, García-Sanz, Ramón, García-Castro, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806455/
https://ncbi.nlm.nih.gov/pubmed/19995953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091050
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