Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

BACKGROUND: The population pharmacokinetics of artesunate (AS) and its active metabolite dihydroartemisinin (DHA) were studied in healthy subjects receiving single- or multiple-dosing of AS orally either in combination with pyronaridine (PYR) or as a monotherapy with or without food. METHODS: Data f...

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Main Authors: Tan, Beesan, Naik, Himanshu, Jang, In-Jin, Yu, Kyung-Sang, Kirsch, Lee E, Shin, Chang-Sik, Craft, J Carl, Fleckenstein, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806381/
https://ncbi.nlm.nih.gov/pubmed/20021657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-8-304
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