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Overall Cdk activity modulates the DNA damage response in mammalian cells
In response to DNA damage, cells activate a phosphorylation-based signaling cascade known as the DNA damage response (DDR). One of the main outcomes of DDR activation is inhibition of cyclin-dependent kinase (Cdk) activity to restrain cell cycle progression until lesions are healed. Recent studies h...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806328/ https://ncbi.nlm.nih.gov/pubmed/19995934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200903033 |
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