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p27(kip1) stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage

One of the current models of cancer proposes that oncogenes activate a DNA damage response (DDR), which would limit the growth of the tumor in its earliest stages. In this context, and in contrast to studies focused on the acute responses to a one-time genotoxic insult, understanding how cells respo...

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Autors principals: Cuadrado, Myriam, Gutierrez-Martinez, Paula, Swat, Aneta, Nebreda, Angel R., Fernandez-Capetillo, Oscar
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594702/
https://ncbi.nlm.nih.gov/pubmed/19843869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0729
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